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Fibroblast Proliferation and Collagen Synthesis In the context of connective tissue repair, fibroblasts are critical for producing and remodeling the extracellular matrix, primarily through collagen synthesis

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NNMT is a cytosolic S-adenosyl-L-methionine-dependent methyltransferase that converts nicotinamide to 1-methylnicotinamide, spending SAM and diverting nicotinamide away from the NAD+ salvage pathway